Sunday, 17 of December of 2017

New Fully Automated Karl Fischer Titration System

AB Controls, Inc., the premier provider of laboratory automation solutions announces that the new Tix system will offer a fully automated robotic system for conducting Karl Fischer moisture assay. The Tix system is validated for use in lyophilization cycle development, tech transfer between various manufacturing sites, and manufacturing discrepancy investigations.

Conventional Karl Fischer titration is not considered a “high throughput” assay and current Karl Fisher Titrators require significant manual intervention from the analyst. This presents a problem when analyzing a large number of samples in a short amount of time. The Tix system, which rids the operators of the tedious task of uncapping, capping, weighing and pouring samples into the cell of the titrator, is a very cost effective tool for saving both time and labor. The efficiency of the process can be viewed with the following video:

According to Mike Nariman, a Senior Systems Architect at AB Controls, “the Tix system integrates an industrial grade robot into a platform ¼ the size of similar systems with 30% more capacity that uses fully integrated sensors.” He then adds: “The beauty of it is that this platform can be used to automate many other processes. Our Focus software allows the scheduling of tasks and batches to be done with ease.”

Mike Nariman coauthored an article in the Pharmaceutical Technology magazine with Dr. Philippe Lam of Genetech who is a user of the system. The article is titled: “A Robust, Automated Karl Fischer Titration System.” AB controls, Inc. (www.abcontrols.com) has also worked with Pfizer, Merck, Amgen, and GlaxoSmithKline. AB Controls, Inc. is continually working to apply the Tix platform to integrate robotic operations into other processes.


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